Association entre
typage HLA et Maladies Auto-Immunes
ASSOCIATION BETWEEN THE
PRESENCE OF VARIOUS HLA MARKES AND SELECTED AUTOIMMUNE DISEASES
DISEASE
|
ASSOCIATED HLA MARKER |
RELATIVE RISK OF DISEASE |
| Ankylosing spondylitis spa
:spondylarthrite |
B27
|
87.4 |
Reactive arthropathy, including
Reiter’s syndrome flr
|
B27 |
37.0 |
Rheumatoid arthritis ra pr : polyarthrite rhumatoide
|
DR 4 |
4.2 |
Behçet’s syndrome
|
B51 |
3.8 |
Systemic lupus erythematosus led lead
|
DR 3 |
5.8 |
Insu in-dependent (type 1) diabetes did
|
DR 3 |
3.3 |
mellitus
|
DQB1*0201 |
2.4 |
| |
D 4
|
6.4 |
DQB1*0302
|
9.5 |
DR 2
|
0.19 |
Idiopathic Addison’s disease
|
DR 3 |
6.3 |
Graves’ disease
|
DR 3 |
3.7 |
Hashimoto’s disease
|
DR 11 |
3.2 |
Postpartum thyroiditis
|
DR 4 |
5.3 |
Celiac disease : Maladie caeliaque
|
DR 3 |
10.8 |
| |
DQB1*0201
|
6.0–10.0 |
| DQA1*0501 |
| DR 7, 11 |
DR 7, DQB1*0201
|
DR 11, DQA1*0501
|
Dermatitis herpetiformis
|
DR 3 |
15.9 |
Sicca syndrome
|
DR 3 |
9.7 |
Myasthenia gravis
|
DR 3 |
2.5 |
B8
|
3.4 |
Idiopathic membranous g omeru-
|
DR 3 |
12.0 |
Goodpasture’s syndrome
|
DR 2 |
15.9 |
Multiple sclerosis
|
DR 2 |
4.1 |
| |
DR B1*1501
|
|
DR B5*0101
|
| DQB1*0602 |
Pemphigus vulgaris (among Ash-kenazi Jews)
|
DR 4 |
14.4
|
Psoriasis vulgaris
|
Cw6 |
13.3 |
Birdshot retinochoroidopathy
|
A29 |
109.0
|
| |
|
|
*Symbols with asterisks indicate alleles, and symbols without asterisks
indicate sero ogica y defined antigens. For each disease, the marker or
markers with the strongest associations are given. In many cases in which
it is difficu t to decide whether HLA-D or DQ markers are responsible
for the association, both markers are given.
†The re ative risk indicates the frequency of a disease in persons with the
HLA marker as compared with persons without the marker. A positive as-sociation (
i.e., when the HLA marker is more frequent in persons with the
disease than in those without it) is indicated by a re ative risk of more than
1.0, a negative association by a re ative risk of ess than 1.0, and no associ-ation
by a re ative risk of 1.0.
‡The risk has not been assessed separate y for this allele.
| |
Copyright
© 2002 Look4 MEDECINE
Dr. sam . Tous droits réservés.
|
